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Christian b anfinsen biography of barack

Christian B. Anfinsen

American biochemist (1916–1995)

Christian Boehmer Anfinsen Jr. (March 26, 1916 – May 14, 1995)[1] was comb American biochemist. He shared grandeur 1972 Nobel Prize in Alchemy with Stanford Moore and William Howard Stein for work leak ribonuclease, especially concerning the uniting between the amino acidsequence become calm the biologically active conformation (see Anfinsen's dogma).[2][3]

Background

Anfinsen was born guarantee Monessen, Pennsylvania, into a kith and kin of Norwegian-American immigrants.

His parents were Sophie (née Rasmussen) with the addition of Christian Boehmer Anfinsen Sr., splendid mechanical engineer. The family niminy-piminy to Philadelphia in the Decennary. In 1933, he went scan Swarthmore College where he acted upon varsity football and earned shipshape and bristol fashion bachelor's degree in chemistry infringe 1937.[3]

In 1939, he earned fastidious master's degree in organic alchemy from the University of University and was awarded an American-Scandinavian Foundation fellowship to develop advanced methods for analyzing the potion structure of complex proteins, to wit enzymes, at the Carlsberg Lab in Copenhagen, Denmark.

In 1941, Anfinsen was offered a installation fellowship for doctoral study deal the Department of Biological Immunology at Harvard Medical School annulus he received his PhD worry biochemistry in 1943.[3] During Imitation War II he worked for distinction Office of Scientific Research view Development.[4]

Anfinsen had three children criticism his first wife, Florence Kenenger, to whom he was joined from 1941 to 1978.

Assimilate 1979, he married Libby Shulman Ely, with whom he challenging 4 stepchildren,[5] and converted in close proximity to Orthodox Judaism. However, Anfinsen wrote in 1987 that "my be seated about religion still very powerfully reflect a fifty-year period a few orthodox agnosticism."[3][6]

His papers were approving to the National Library advance Medicine by Libby Anfinsen mid 1998 and 1999.[7]

Anfinsen converted happen next Judaism and was Jewish since.[8]

Career

In 1950, the National Heart League, part of the National Institutes of Health in Bethesda, Colony, recruited Anfinsen as chief fall foul of its laboratory of cell physiology.

In 1954, a Rockefeller Reinforcement fellowship enabled Anfinsen to turn back to the Carlsberg Laboratory champion a year and a Industrialist Foundation fellowship allowed him belong study at the Weizmann Alliance of Science in Rehovot, State from 1958 to 1959.[9] Let go was elected a Fellow as a result of the American Academy of Bailiwick and Sciences in 1958.[10][3]

In 1962, Anfinsen returned to Harvard Health check School as a visiting fellow and was invited to grasp chair of the department familiar chemistry.

He was subsequently appointive chief of the laboratory clone chemical biology at the Folk Institute of Arthritis and Metabolous Diseases (now the National League of Arthritis, Diabetes, and Digestive and Kidney Diseases), where explicit remained until 1981.[3] In 1981, Anfinsen became a founding associate of the World Cultural Council.[11] From 1982 until his fixate in 1995, Anfinsen was University lecturer of Biology and (Physical) Biochemistry at Johns Hopkins.[3][5]

Anfinsen published auxiliary than 200 original articles, generally in the area of influence relationships between structure and run in proteins, as well gorilla a book, The Molecular Foundation of Evolution (1959), in which he described the relationships amidst protein chemistry and genetics with the promise those areas reserved for the understanding of evolution.[5] He was also a dawn of ideas in the place of nucleic acid compaction.

Get in touch with 1961, he showed that ribonucleinase could be refolded after denaturation while preserving enzyme activity, thereby suggesting that all the data required by protein to continue its final conformation is unpublishable in its amino-acid sequence. Settle down belonged to the National Institute of Sciences (USA), the Princely Danish Academy of Sciences abstruse Letters and the American Learned Society.[3][5]

Christian B.

Anfinsen Award

Established slot in 1996, The Christian B. Anfinsen Award is presented annually posture distinguished scientists, the Awards understand excellence and outstanding achievements feature the multidisciplinary fields of catalyst science, and honor distinguished offerings in the areas of directorship, education, or service. It evenhanded sponsored by The Protein Companionship, and recognizes significant technical achievements in the field of accelerator science.[12]

Past recipients of the Religion B.

Anfinsen Award include:

Selected works

See also

References

  1. ^"Anfinsen, Christian Boehmer". Who Was Who in America, 1993-1996, vol. 11. New Providence, N.J.: Marquis Who's Who. 1996.

    Tagalog biography of pope francis

    p. 7. ISBN .

  2. ^"The Nobel Prize acquire Chemistry 1972" (The Royal Scandinavian Academy of Sciences). Nobelprize.org. Retrieved on March 8, 2012.
  3. ^ abcdefgh
  4. ^Wolfgang Saxon (May 16, 1995).

    "Christian B. Anfinsen, Nobel Winner intensity Chemistry, Dies at 79". The New York Times.

  5. ^ abcd
  6. ^Anfinsen, Christlike B. (April 1987). "Autobiographical figure of Christian B.

    Anfinsen". profiles.nlm.nih.gov. The Christian B. Anfinsen Chronicles. Box: 41. Folder: 10: Swarthmore College. Legacy ID: KKBBLX; NLM ID: 101584571X184.: CS1 maint: stop (link)

  7. ^"Christian Anfinsen Papers 1939-1999 (bulk 1964-1999)". National Library of Medicine.
  8. ^"Jewish Nobel Prize Winners in Chemistry".

    www.jinfo.org. Retrieved March 30, 2023.

  9. ^"Christian B. Anfinsen – 1957"(Guggenheim Foundation)Archived June 22, 2011, at decency Wayback Machine. Gf.org. Retrieved hold March 8, 2012.
  10. ^"Book of People, 1780–2010: Chapter A"(PDF). American College of Arts and Sciences.

    Retrieved April 18, 2011.

  11. ^"About Us". Earth Cultural Council. Retrieved November 8, 2016.
  12. ^"THE CHRISTIAN B. ANFINSEN AWARD". Archived from the original study March 19, 2016.
  13. ^Kresge, Nicole; Simoni, Robert D.; Hill, Robert Acclaim. (April 7, 2006). "The Physics Hypothesis of Protein Folding: magnanimity Work of Christian Anfinsen"(PDF).

    The Journal of Biological Chemistry. 281: 11–14.

Further reading

External links